Cryptic crossword clue
Tame doc meditates after major surgery 12

The most common and most likely answer to this crossword clue is the 12 letter word DOMESTICATED

I've seen this crossword clue in The Times
D
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Buddy explains!

The straight part
We know that "Tame" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case tame = domesticated.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DOMESTICATED mean?

DOMESTICATED verb
  1. To make domestic.
  2. To make fit for domestic life.
  3. To adapt to live with humans.
  4. To adapt to live with humans.
  5. To make a legal instrument recognized and enforceable in a jurisdiction foreign to the one in which the instrument was originally issued or created.
  6. To amend the elements of a text to fit local culture.
DOMESTICATED adjective
  1. (of an animal or a plant, especially a pet) selectively bred to live with or around humans.

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