The most common and most likely answer to this crossword clue is the 6 plus 4 letter word MORTAL BLOW
I've seen this crossword clue in The Guardian
M
O
R
T
A
L
B
L
O
W
Buddy explains!
The straight part
We know that "ultimate hit" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case ultimate hit = mortal blow.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.