The most common and most likely answer to this crossword clue is the 8 letter word IRRITANT
I've seen this crossword clue in The Daily Telegraph
I
R
R
I
T
A
N
T
More clues leading to the result IRRITANT
- Annoying train, it runs irregularly
- Trouble girl to make entry in old tax office books
- Irish girl joins National Trust – a cause of annoyance
- Annoyance: a lot of anger and rage about it
- Itch making one declaim, about to scratch
- Trouble girl to fill in Tax Office books
- Pain in rear starts slowing down worker
- Miss Hayworth’s aboard faulty train — a damned nuisance…
- Taxman getting it in angry tirade is a nuisance
- Limousine with Tina Turner in it is cause for excitement
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does IRRITANT mean?
IRRITANT noun- Any medication designed to cause irritation
- A source of irritation.
- Causing irritation or inflammation.
- Rendering null and void; conditionally invalidating.