Cryptic crossword clue
Teacher in toupee rejected by university 4

The most common and most likely answer to this crossword clue is the 4 letter word GURU

I've seen this crossword clue in Financial Times
G
U
R
U


Buddy explains!

The straight part
We know that "Teacher" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case teacher = guru.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GURU mean?

GURU noun
  1. A Hindu or Sikh spiritual teacher.
  2. (sometimes humorous) An influential advisor or mentor.

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