The most common and most likely answer to this crossword clue is the 8 letter word LIVERISH
I've seen this crossword clue in The Guardian
L
I
V
E
R
I
S
H
More clues leading to the result LIVERISH
Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does LIVERISH mean?
LIVERISH adjective- Not feeling well due to an upset digestive system; queasy.