Cryptic crossword clue
Tease hit man unsettled by a curse

The most common and most likely answer to this crossword clue is the 12 letter word ANATHEMATISE

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "curse" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case curse = anathematise.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ANATHEMATISE mean?

ANATHEMATISE verb
  1. To cause to be, or to declare as, an anathema or evil.

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