Cryptic crossword clue
Tedium starts to exhaust now nothing usually interests 5

The most common and most likely answer to this crossword clue is the 5 letter word ENNUI

I've seen this crossword clue in The Times
E
N
N
U
I


Buddy explains!

The straight part
We know that "Tedium" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case tedium = ennui.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ENNUI mean?

ENNUI noun
  1. A gripping listlessness or melancholia caused by boredom; depression.
ENNUI verb
  1. To make bored or listless; to weary.

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