Cryptic crossword clue
Tendency to sin, evidently demonstrates constituent of DNA 8

The most common and most likely answer to this crossword clue is the 8 letter word CYTOSINE

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Buddy explains!

The straight part
We know that "constituent of DNA" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case constituent of dna = cytosine.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CYTOSINE mean?

CYTOSINE noun
  1. A heterocyclic base, 4-aminopyrimidin-2(1H)-one, which pairs with guanine in DNA and RNA (by means of three hydrogen bonds).

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