Cryptic crossword clue
Tenderloin like this is bathed in juice when flipped 5

The most common and most likely answer to this crossword clue is the 5 letter word PSOAS

P
S
O
A
S

Buddy explains!

The straight part
We know that "Tenderloin" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case tenderloin = psoas.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PSOAS mean?

PSOAS noun
  1. Either of two muscles, the psoas major and psoas minor, involved in flexion of the trunk.

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