The most common and most likely answer to this crossword clue is the 4 letter word TIRE
I've seen this crossword clue in The Daily Telegraph
T
I
R
E
More clues leading to the result TIRE
- Part of American car — exhaust?
- Flag that is reluctantly exhibited first of all
- Exhaust? It’s part of vehicle in LA
- Obligation to carry right flag
- Exhaust and wheel fitting
- Peers into regularly backed-up drain
- Tense annoyance creates fatigue
- After bringing it back again, show fatigue
- Regressive attribute of Inheritance Tax
- Exhaust seen on American car
Buddy explains!
The straight part
We know that "fatigue" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case fatigue = tire.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does TIRE mean?
TIRE verb- To become sleepy or weary.
- To make sleepy or weary.
- To become bored or impatient (with).
- To bore.
- Accoutrements, accessories.
- Dress, clothes, attire.
- A covering for the head; a headdress.
- Metal rim of a wheel, especially that of a railroad locomotive.
- The rubber covering on a wheel; a tyre.
- A child's apron covering the upper part of the body, and tied with tape or cord; a pinafore. Also tier.
- To dress or adorn.
- To seize, pull, and tear prey, as a hawk does.
- To seize, rend, or tear something as prey; to be fixed upon, or engaged with, anything.
- A tier, row, or rank.