Cryptic crossword clue
Tentatively propose sin as a tyrant’s thing 10

The most common and most likely answer to this crossword clue is the 10 letter word OPPRESSION

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "a tyrant’s thing" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case a tyrant’s thing = oppression.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does OPPRESSION mean?

OPPRESSION noun
  1. The exercise of authority or power in a burdensome, cruel, or unjust manner.
  2. The act of oppressing, or the state of being oppressed.
  3. A feeling of being oppressed.

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