The most common and most likely answer to this crossword clue is the 8 letter word ASTHENIA
I've seen this crossword clue in The Times
A
S
T
H
E
N
I
A
More clues leading to the result ASTHENIA
- Lack of energy, say? So I start on antibiotics
- Tequilas, then I am hiding fatigue
- Debility in one half of continent followed by the other
- Debility at that time within continent
- Weakness those days being incontinent, spaced out
- Next, in the continent there will be energy deficiency
- Heat is an irritant, leads to lack of energy
- Abnormal loss of strength for the model attached to a bird entering the continent
Buddy explains!
The straight part
We know that "fatigue" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case fatigue = asthenia.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ASTHENIA mean?
ASTHENIA noun- Weakness; loss of strength.