The most common and most likely answer to this crossword clue is the 9 letter word TERATOGEN
I've seen this crossword clue in Financial Times
T
E
R
A
T
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Buddy explains!
The straight part
We know that "something detrimental in early stages of life" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case something detrimental in early stages of life = teratogen.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does TERATOGEN mean?
TERATOGEN noun- Any agent or substance which can cause malformation of an embryo or birth defects.