The most common and most likely answer to this crossword clue is the 6 letter word MARGIN
M
A
R
G
I
N
More clues leading to the result MARGIN
- Mother right - drink makes difference!
- Place to make a note of profit
- Thatcher’s Left side accepted latitude
- Starts to mount armed resistance against soldier on northern border
- Initially, Ricky Gervais featured in the most important side
- Limit damage produced by drink
- Sheepish male knocked over drink? Allowance must be made
- Poison drink? That’s the limit!
- Ruin mother’s ruin? That’s the limit!
- Sheep falling over trap in border area
Buddy explains!

The straight part
We know that "latitude" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case latitude = margin.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MARGIN mean?
MARGIN noun- The edge of the paper, typically left blank when printing but sometimes used for annotations etc.
- The edge or border of any flat surface.
- The edge defining inclusion in or exclusion from a set or group.
- A difference or ratio between results, characteristics, scores.
- A permissible difference; allowing some freedom to move within limits.
- The yield or profit; the selling price minus the cost of production.
- Collateral security deposited with a broker, to compensate the broker in the event of loss in the speculative buying and selling of stocks, commodities, etc.
- To add a margin to.
- To enter (notes etc.) into the margin.