Cryptic crossword clue
The end of Her Excellency’s nipple is a wee bit painful 8

The most common and most likely answer to this crossword clue is the 8 letter word CYSTITIS

I've seen this crossword clue in Financial Times
C
Y
S
T
I
T
I
S

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CYSTITIS mean?

CYSTITIS noun
  1. Inflammation of the urinary bladder.

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