Cryptic crossword clue
The heart of luminance reveals the location of Canopus 6

The most common and most likely answer to this crossword clue is the 6 letter word CARINA

I've seen this crossword clue in The Guardian
C
A
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N
A

Buddy explains!

The straight part
We know that "the location of Canopus" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case the location of canopus = carina.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CARINA mean?

CARINA noun
  1. A longitudinal ridge or projection like the keel of a boat.
  2. Part of a papilionaceous flower consisting of two petals, commonly united, which encloses the organs of fructification.
  3. The keel of the breastbone of birds.
  4. Any of several features that have a projecting central ridge

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