Cryptic crossword clue
The Italian Sue's undergone operation for intestinal obstruction 5

The most common and most likely answer to this crossword clue is the 5 letter word ILEUS

I
L
E
U
S

Buddy explains!

The straight part
We know that "intestinal obstruction" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case intestinal obstruction = ileus.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ILEUS mean?

ILEUS noun
  1. (modern usage) Disruption of the normal propulsive ability of the gastrointestinal tract, due to failure of peristalsis.
  2. (broad definition, now rare) Disruption of the normal propulsive ability of the gastrointestinal tract from any cause.

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