Cryptic crossword clue
The Italian’s left with head cold perhaps 7

The most common and most likely answer to this crossword clue is the 7 letter word ILLNESS

I've seen this crossword clue in The Daily Telegraph
I
L
L
N
E
S
S


Buddy explains!

The straight part
We know that "cold perhaps" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case cold perhaps = illness.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ILLNESS mean?

ILLNESS noun
  1. An instance of a disease or poor health.
  2. A state of bad health or disease.

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