The most common and most likely answer to this crossword clue is the 12 letter word PALINGENESIS
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does PALINGENESIS mean?
PALINGENESIS noun- The apparent repetition, during the development of a single embryo, of changes that occurred previously in the evolution of its species.
- The regeneration of magma by the melting of metamorphic rocks.
- Spiritual rebirth through the transmigration of the soul.
- (more generally) Rebirth; regeneration.
- The recurrence of historical events in the same order in an infinite series of cycles.