The most common and most likely answer to this crossword clue is the 11 letter word MATERIALIST
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Buddy explains!
The straight part
We know that "who denies the spiritual" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case who denies the spiritual = materialist.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MATERIALIST mean?
MATERIALIST noun- Someone who is materialistic, concerned only with material possessions.
- A follower or proponent of philosophical materialism.
- Having features typical of philosophical materialism.