Cryptic crossword clue
The Spanish family initially left by artist in pose for his picture? 4-8

The most common and most likely answer to this crossword clue is the 13 letter word SELF-PORTRAIT

I've seen this crossword clue in The Times
S
E
L
F
-
P
O
R
T
R
A
I
T

Buddy explains!

The straight part
We know that "his picture" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case his picture = self-portrait.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SELF-PORTRAIT mean?

SELF-PORTRAIT noun
  1. The bust of an artist by the artist him/herself; a portrait of the painter who painted it.

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