Cryptic crossword clue
The Vatican's one English hub accommodates 150 7

The most common and most likely answer to this crossword clue is the 7 letter word ENCLAVE

I've seen this crossword clue in The Times
E
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A
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Buddy explains!

The straight part
We know that "The Vatican's one" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case the vatican's one = enclave.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ENCLAVE mean?

ENCLAVE noun
  1. A political, cultural or social entity or part thereof that is completely surrounded by another.
  2. A group that is set off from a larger population by its characteristic or behavior.
  3. An isolated portion of an application's address space, such that data in an enclave can only be accessed by code in the same enclave.
ENCLAVE verb
  1. To enclose within a foreign territory.

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