Cryptic crossword clue
Their depredations affect the stockholders 8

The most common and most likely answer to this crossword clue is the 8 letter word RUSTLERS

I've seen this crossword clue in The Daily Telegraph
R
U
S
T
L
E
R
S

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RUSTLERS mean?

RUSTLERS noun
  1. One who rustles; a cattle (or other livestock) thief.
  2. A bovine animal that can care for itself in any circumstances.
  3. (Western US) An alert, energetic, driving person.
  4. That which makes a rustling noise.

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