Cryptic crossword clue
Their mum’s a different cause of much pain 10

The most common and most likely answer to this crossword clue is the 10 letter word RHEUMATISM

I've seen this crossword clue in The Daily Telegraph
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Buddy explains!

The straight part
We know that "cause of much pain" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case cause of much pain = rheumatism.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RHEUMATISM mean?

RHEUMATISM noun
  1. Any disorder of the muscles, tendons, joints, bones, nerves, characterized by pain, discomfort and disability.
  2. Atrophic arthritis, rheumatoid arthritis

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