Cryptic crossword clue
Then guides in ruins can be a blessing 10

The most common and most likely answer to this crossword clue is the 10 letter word GESUNDHEIT

G
E
S
U
N
D
H
E
I
T

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GESUNDHEIT mean?

GESUNDHEIT interjection
  1. Said to someone who has just sneezed.
  2. Said as a response to someone who said something difficult or convoluted.

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