The most common and most likely answer to this crossword clue is the 10 letter word SERVIETTES
I've seen this crossword clue in The Daily Telegraph
S
E
R
V
I
E
T
T
E
S
More clues leading to the result SERVIETTES
Buddy explains!
The straight part
We know that "These protect against spills" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case these protect against spills = serviettes.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SERVIETTES mean?
SERVIETTES noun- A table napkin, now especially a paper one.
- A lazy Susan