Cryptic crossword clue
Thespian's angst ruined the first gag 5,6

The most common and most likely answer to this crossword clue is the 11 letter word STAGEFRIGHT

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does STAGEFRIGHT mean?

STAGEFRIGHT noun
  1. A state of nervousness about performing some action in front of a group of people, on or off of a stage; nerves; a lack of self-assurance before an audience.

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