Cryptic crossword clue
They are fired on ISS in great distance 8

The most common and most likely answer to this crossword clue is the 8 letter word MISSILES

M
I
S
S
I
L
E
S

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The straight part
We know that "They are fired" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case they are fired = missiles.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MISSILES mean?

MISSILES noun
  1. Any object used as a weapon by being thrown or fired through the air, such as stone, arrow or bullet.
  2. A self-propelled projectile whose trajectory can be adjusted after it is launched.

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