The most common and most likely answer to this crossword clue is the 11 letter word THUMBPIECES
I've seen this crossword clue in The Times
T
H
U
M
B
P
I
E
C
E
S
Buddy explains!
The straight part
We know that "They can be depressed by what it takes to hitch-hike!" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case they can be depressed by what it takes to hitch-hike! = thumbpieces.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.