Cryptic crossword clue
They can become inflated, say, and very large 4

The most common and most likely answer to this crossword clue is the 4 letter word EGOS

I've seen this crossword clue in The Daily Telegraph
E
G
O
S


Buddy explains!

The straight part
We know that "They can become inflated" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case they can become inflated = egos.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EGOS mean?

EGOS noun
  1. The self, especially with a sense of self-importance.
  2. (Freudian) The most central part of the mind, which mediates with one's surroundings.

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