Cryptic crossword clue
They could be vacant females taking debauched one inside? 8

The most common and most likely answer to this crossword clue is the 8 letter word FLOOSIES

I've seen this crossword clue in The Guardian
F
L
O
O
S
I
E
S

Buddy explains!

The straight part
We know that "They could be" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case they could be = floosies.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does FLOOSIES mean?

FLOOSIES noun
  1. A vulgar or sexually promiscuous woman; a hussy or slattern.
  2. A prostitute who attracts customers by walking the streets.

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