The most common and most likely answer to this crossword clue is the 5 plus 7 letter word RADIO BEACONS
R
A
D
I
O
B
E
A
C
O
N
S
Buddy explains!
The straight part
We know that "They guide pilots by area" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case they guide pilots by area = radio beacons.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.