Cryptic crossword clue
They help gamblers and prostitutes missing out having a flutter 8

The most common and most likely answer to this crossword clue is the 8 letter word TIPSTERS

I've seen this crossword clue in The Guardian
T
I
P
S
T
E
R
S

Buddy explains!

The straight part
We know that "They help gamblers" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case they help gamblers = tipsters.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TIPSTERS mean?

TIPSTERS noun
  1. A person who provides tips or advice to others, for example on the form of racehorses or the stock market.
  2. One who provides tips or hints on how to succeed at a game.

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