Cryptic crossword clue
They keep staying awake in casinos, desperate to win money 10

The most common and most likely answer to this crossword clue is the 10 letter word INSOMNIACS

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Buddy explains!

The straight part
We know that "They keep staying awake" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case they keep staying awake = insomniacs.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INSOMNIACS mean?

INSOMNIACS noun
  1. One who suffers an inability or difficulty sleeping; a sufferer from insomnia.

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