Cryptic crossword clue
They manage sir’s pain 8

The most common and most likely answer to this crossword clue is the 8 letter word ASPIRINS

I've seen this crossword clue in The Guardian
A
S
P
I
R
I
N
S

Buddy explains!

The straight part
We know that "They manage sir’s pain /They manage sir’s pain" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case they manage sir’s pain /they manage sir’s pain = aspirins.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ASPIRINS mean?

ASPIRINS noun
  1. An analgesic drug, acetylsalicylic acid
  2. A tablet containing this substance

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