The most common and most likely answer to this crossword clue is the 13 letter word DECONGESTANTS
I've seen this crossword clue in The Daily Telegraph
D
E
C
O
N
G
E
S
T
A
N
T
S
More clues leading to the result DECONGESTANTS
Buddy explains!
The straight part
We know that "They may help folk get things off their chest" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case they may help folk get things off their chest = decongestants.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does DECONGESTANTS mean?
DECONGESTANTS noun- A drug that relieves congestion, e.g. pseudoephedrine.