Cryptic crossword clue
This may indicate a late sherry got drunk after opening of brandy!

The most common and most likely answer to this crossword clue is the 12 letter word BREATHALYSER

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "This may indicate a late sherry got drunk after opening of brandy" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case this may indicate a late sherry got drunk after opening of brandy = breathalyser.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does BREATHALYSER mean?

BREATHALYSER noun
  1. A device that measures alcohol in expired air so as to estimate the concentration of alcohol in a person's blood; used by traffic police in cases of suspected driving while under the influence of alcohol.

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