Cryptic crossword clue
This stupid guy hosting one person from Panama, say 8

The most common and most likely answer to this crossword clue is the 8 letter word ISTHMIAN

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Buddy explains!

The straight part
We know that "from Panama, say" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case from panama, say = isthmian.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ISTHMIAN mean?

ISTHMIAN noun
  1. A native or inhabitant of an isthmus.
ISTHMIAN adjective
  1. Of or pertaining to an isthmus, especially to the Isthmus of Corinth, in Greece.

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