Cryptic crossword clue
Those showing no appreciation could make one angriest 8

The most common and most likely answer to this crossword clue is the 8 letter word INGRATES

I've seen this crossword clue in The Daily Telegraph
I
N
G
R
A
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E
S


Buddy explains!

The straight part
We know that "Those showing no appreciation" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case those showing no appreciation = ingrates.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INGRATES mean?

INGRATES noun
  1. An ungrateful person

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