The most common and most likely answer to this crossword clue is the 5 letter word CLADE
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Buddy explains!
The straight part
We know that "Those with a common ancestor" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case those with a common ancestor = clade.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does CLADE mean?
CLADE noun- A group of animals or other organisms derived from a common ancestor species.
- A higher level grouping of a genetic haplogroup.
- To be part of a clade; to form a clade.