Cryptic crossword clue
Ticklish case in infectious air? One going underground 9

The most common and most likely answer to this crossword clue is the 9 letter word EARTHWORM

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "One going underground" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one going underground = earthworm.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EARTHWORM mean?

EARTHWORM noun
  1. A worm that lives in the ground.
  2. A worm of the family Lumbricidae, or, more generally, of the suborder Lumbricina.
  3. A contemptible person; a groveller.

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