Cryptic crossword clue
Time and again, best three-quarters appear most frequently

The most common and most likely answer to this crossword clue is the 8 letter word OFTENEST

I've seen this crossword clue in The Guardian
O
F
T
E
N
E
S
T

Buddy explains!

The straight part
We know that "most frequently" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case most frequently = oftenest.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does OFTENEST mean?

OFTENEST adverb
  1. Frequently, many times.

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