Cryptic crossword clue
Time off in German region half wasted 4

The most common and most likely answer to this crossword clue is the 4 letter word HOLS

H
O
L
S

Buddy explains!

The straight part
We know that "Time off" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case time off = hols.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HOLS mean?

HOLS noun
  1. Holidays (time off work or time spent travelling).

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