Cryptic crossword clue
Time’s against Shakespeare’s wife? Husband’s off in the direction indicated 8

The most common and most likely answer to this crossword clue is the 8 letter word THATAWAY

I've seen this crossword clue in The Guardian
T
H
A
T
A
W
A
Y


Buddy explains!

The straight part
We know that "in the direction indicated" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case in the direction indicated = thataway.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does THATAWAY mean?

THATAWAY adverb
  1. That way (usually in terms of physical direction)

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