The most common and most likely answer to this crossword clue is the 4 plus 2 plus 9 letter word WHAT IN TARNATION
I've seen this crossword clue in The Guardian
W
H
A
T
I
N
T
A
R
N
A
T
I
O
N
Buddy explains!
The straight part
We know that "eh?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case eh? = what in tarnation.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.