Cryptic crossword clue
Tiny animal reserve close to small river

The most common and most likely answer to this crossword clue is the 9 letter word BOOKLOUSE

I've seen this crossword clue in The Times
B
O
O
K
L
O
U
S
E

Buddy explains!

The straight part
We know that "Tiny animal" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case tiny animal = booklouse.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does BOOKLOUSE mean?

BOOKLOUSE noun
  1. Any of the small insects who feed on bookbindings, especially those of the order Psocoptera.

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