The most common and most likely answer to this crossword clue is the 6 letter word PSYCHE
I've seen this crossword clue in The Guardian
P
S
Y
C
H
E
More clues leading to the result PSYCHE
- Autopsy check’s far from complete, mind
- Blasted hype is full of cold soul
- In Metamorphoses, yes, chap is acting with this lover of Eros
- Leaders of party salute your revolutionary spirit
- . Spy’s converted by revolutionary spirit
- Tipsy Chechens, full of spirit
- Spy cracked revolutionary mind
- Afterthought in letter by Young Conservative leads to Henry’s effusive spirit
- Soul of tipsy Cherokee
- Mind seeing short film by head of Ealing
Buddy explains!

The straight part
We know that "spirit" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case spirit = psyche.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does PSYCHE mean?
PSYCHE noun- The human soul, mind, or spirit.
- (chiefly psychology) The human mind as the central force in thought, emotion, and behavior of an individual.
- A small white butterfly, Leptosia nina, family Pieridae, of Asia and Australasia.
- To put (someone) into a required psychological frame of mind.
- To intimidate (someone) emotionally using psychology.
- To treat (someone) using psychoanalysis.
- Used abruptly after a sentence to indicate that the speaker is only joking.
- The study of the human mind.
- The study of human behavior.
- The study of animal behavior.
- The mental, emotional, and behavioral characteristics pertaining to a specified person, group, or activity.