Cryptic crossword clue
Tireless working to keep one clean 9

The most common and most likely answer to this crossword clue is the 9 letter word STERILISE

I've seen this crossword clue in The Guardian
S
T
E
R
I
L
I
S
E

Buddy explains!

The straight part
We know that "clean" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case clean = sterilise.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does STERILISE mean?

STERILISE verb
  1. To deprive of the ability to procreate.
  2. To make unable to produce; to make unprofitable.
  3. To kill, deactivate (denature), or destroy (break apart) all living, viable microorganisms and spores on a surface, in a fluid, or contained in a compound, such as culture media or a medical product.
  4. To redact (a document), removing classified or sensitive material.

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