Cryptic crossword clue
Tissue frameworks giving support – second’s folded in layers 8

The most common and most likely answer to this crossword clue is the 8 letter word STROMATA

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Buddy explains!

The straight part
We know that "Tissue frameworks giving support" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case tissue frameworks giving support = stromata.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does STROMATA mean?

STROMATA noun
  1. The tissue structure of an organ, etc., that serves to support it.

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