Cryptic crossword clue
To depose his best lad is misguided 12

The most common and most likely answer to this crossword clue is the 12 letter word DISESTABLISH

I've seen this crossword clue in The Times
D
I
S
E
S
T
A
B
L
I
S
H

Buddy explains!

The straight part
We know that "To depose" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case to depose = disestablish.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DISESTABLISH mean?

DISESTABLISH verb
  1. To deprive (an established church, military squadron, operations base, etc.) of its official status.
  2. To abolish (an existing position of employment).

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